Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/−) mice

BACKGROUND: Type 2 diabetes (T2DM) is an age-associated disease characterized by hyperglycemia due to insulin resistance and decreased beta-cell function. DNA damage accumulation has been associated with T2DM, but whether DNA damage plays a role in the pathogenesis of the disease is unclear. Here, w...

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Detalles Bibliográficos
Autores principales: Huerta Guevara, Ana P., McGowan, Sara J., Kazantzis, Melissa, Stallons, Tania Rozgaja, Sano, Tokio, Mulder, Niels L., Jurdzinski, Angelika, van Dijk, Theo H., Eggen, Bart J.L., Jonker, Johan W., Niedernhofer, Laura J., Kruit, Janine K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625516/
https://www.ncbi.nlm.nih.gov/pubmed/33493548
http://dx.doi.org/10.1016/j.metabol.2021.154711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625516/
https://www.ncbi.nlm.nih.gov/pubmed/33493548
http://dx.doi.org/10.1016/j.metabol.2021.154711

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