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Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl(−)/H(+) Antiporter
Intracellular transport of chloride by members of the CLC transporter family involves a coupled exchange between a Cl(−) anion and a proton (H(+)), which makes the transport function dependent on ambient pH. Transport activity peaks at pH 4.5 and stalls at neutral pH. However, a structure of the WT...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625536/ https://www.ncbi.nlm.nih.gov/pubmed/34834047 http://dx.doi.org/10.3390/molecules26226956 |