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Simulation of pH-Dependent Conformational Transitions in Membrane Proteins: The CLC-ec1 Cl(−)/H(+) Antiporter

Intracellular transport of chloride by members of the CLC transporter family involves a coupled exchange between a Cl(−) anion and a proton (H(+)), which makes the transport function dependent on ambient pH. Transport activity peaks at pH 4.5 and stalls at neutral pH. However, a structure of the WT...

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Detalles Bibliográficos
Autores principales:	Kots, Ekaterina, Shore, Derek M., Weinstein, Harel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625536/ https://www.ncbi.nlm.nih.gov/pubmed/34834047 http://dx.doi.org/10.3390/molecules26226956

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