Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors

A series of benzenesulfonamides incorporating pyrazole- and pyridazinecarboxamides decorated with several bulky moieties has been obtained by original procedures. The new derivatives were investigated for the inhibition of four physiologically crucial human carbonic anhydrase (hCA, EC 4.2.2.1.1) iso...

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Detalles Bibliográficos
Autores principales: Angeli, Andrea, Kartsev, Victor, Petrou, Anthi, Pinteala, Mariana, Brovarets, Volodymyr, Vydzhak, Roman, Panchishin, Svitlana, Geronikaki, Athina, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625619/
https://www.ncbi.nlm.nih.gov/pubmed/34834114
http://dx.doi.org/10.3390/molecules26227023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625619/
https://www.ncbi.nlm.nih.gov/pubmed/34834114
http://dx.doi.org/10.3390/molecules26227023

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