A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due to defects in Gag/GagPol processing by inhibit...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Hao, Ming, Khan, Muhammad A., Rehman, Muhammad T., Highbarger, Helene C., Chen, Qian, Goswami, Suranjana, Sherman, Brad T., Rehm, Catherine A., Dewar, Robin L., Chang, Weizhong, Imamichi, Tomozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625782/
https://www.ncbi.nlm.nih.gov/pubmed/34835137
http://dx.doi.org/10.3390/v13112331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625782/
https://www.ncbi.nlm.nih.gov/pubmed/34835137
http://dx.doi.org/10.3390/v13112331

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