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Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway
BACKGROUND: Intervertebral disc is responsible for absorbing and transmitting mechanical compression. Under physiological conditions, the peripheral annulus fibrosus (AF) cells are subjected to different magnitudes of transverse mechanical stretch depending on the swelling of the central nucleus pul...
Autores principales: | Ning, Li, Gao, Lei, Zhang, Fan, Li, Xiaoxiao, Wang, Tingting |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626192/ https://www.ncbi.nlm.nih.gov/pubmed/34840974 http://dx.doi.org/10.1155/2021/5321121 |
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