Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Microbes produce a broad spectrum of antibiotic natural products, including many DNA-damaging genotoxins. Among the most potent of these are DNA alkylating agents in the spirocyclopropylcyclohexadienone (SCPCHD) family, which includes the duocarmycins, CC-1065, gilvusmycin, and yatakemycin. The yata...

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Detalles Bibliográficos
Autores principales: Mullins, Elwood A., Dorival, Jonathan, Tang, Gong-Li, Boger, Dale L., Eichman, Brandt F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626424/
https://www.ncbi.nlm.nih.gov/pubmed/34836957
http://dx.doi.org/10.1038/s41467-021-27284-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626424/
https://www.ncbi.nlm.nih.gov/pubmed/34836957
http://dx.doi.org/10.1038/s41467-021-27284-7

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