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Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites
Microbes produce a broad spectrum of antibiotic natural products, including many DNA-damaging genotoxins. Among the most potent of these are DNA alkylating agents in the spirocyclopropylcyclohexadienone (SCPCHD) family, which includes the duocarmycins, CC-1065, gilvusmycin, and yatakemycin. The yata...
Autores principales: | Mullins, Elwood A., Dorival, Jonathan, Tang, Gong-Li, Boger, Dale L., Eichman, Brandt F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626424/ https://www.ncbi.nlm.nih.gov/pubmed/34836957 http://dx.doi.org/10.1038/s41467-021-27284-7 |
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