Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

Chronic exposure to high levels of manganese (Mn) leads to manganism, a neurological disorder with similar symptoms to those inherent to Parkinson's disease. However, the underlying mechanisms of this pathological condition have yet to be established. Since the human excitatory amino acid trans...

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Detalles Bibliográficos
Autores principales: Pajarillo, Edward, Digman, Alexis, Nyarko-Danquah, Ivan, Son, Deok-Soo, Soliman, Karam F.A., Aschner, Michael, Lee, Eunsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626589/
https://www.ncbi.nlm.nih.gov/pubmed/34756885
http://dx.doi.org/10.1016/j.jbc.2021.101372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626589/
https://www.ncbi.nlm.nih.gov/pubmed/34756885
http://dx.doi.org/10.1016/j.jbc.2021.101372

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