Successful Prediction of Human Fetal Exposure to P-Glycoprotein Substrate Drugs Using the Proteomics-Informed Relative Expression Factor Approach and PBPK Modeling and Simulation

Many women take drugs during their pregnancy to treat a variety of clinical conditions. To optimize drug efficacy and reduce fetal toxicity, it is important to determine or predict fetal drug exposure throughout pregnancy. Previously, we developed and verified a maternal-fetal physiologically based...

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Detalles Bibliográficos
Autores principales: Anoshchenko, Olena, Storelli, Flavia, Unadkat, Jashvant D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626637/
https://www.ncbi.nlm.nih.gov/pubmed/34426410
http://dx.doi.org/10.1124/dmd.121.000538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626637/
https://www.ncbi.nlm.nih.gov/pubmed/34426410
http://dx.doi.org/10.1124/dmd.121.000538

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