Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA

Microtubule-targeting agents (MTAs), including both microtubule stabilizers and destabilizers are highly effective chemotherapeutic drugs used in the treatment of solid tumors and hematologic malignancies. In addition to the shared ability of all MTAs to block cell cycle progression, growing evidenc...

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Detalles Bibliográficos
Autores principales: Fermaintt, Charles S., Takahashi-Ruiz, Leila, Liang, Huiyun, Mooberry, Susan L., Risinger, April L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626644/
https://www.ncbi.nlm.nih.gov/pubmed/34312217
http://dx.doi.org/10.1124/molpharm.121.000297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626644/
https://www.ncbi.nlm.nih.gov/pubmed/34312217
http://dx.doi.org/10.1124/molpharm.121.000297

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