Cargando…

Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA

Microtubule-targeting agents (MTAs), including both microtubule stabilizers and destabilizers are highly effective chemotherapeutic drugs used in the treatment of solid tumors and hematologic malignancies. In addition to the shared ability of all MTAs to block cell cycle progression, growing evidenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fermaintt, Charles S., Takahashi-Ruiz, Leila, Liang, Huiyun, Mooberry, Susan L., Risinger, April L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626644/ https://www.ncbi.nlm.nih.gov/pubmed/34312217 http://dx.doi.org/10.1124/molpharm.121.000297

Ejemplares similares

429 Eribulin Synergizes with STING Agonists by Enhancing Type 1 Interferon Expression and Improves Antitumor Efficacy as Combination Treatment
por: Takahashi-Ruiz, Leila, et al.
Publicado: (2023)

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models
por: Takahashi-Ruiz, Leila, et al.
Publicado: (2022)

Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner
por: Kaul, Roma, et al.
Publicado: (2019)

Correction: Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner
por: Kaul, Roma, et al.
Publicado: (2020)

Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin
por: Dybdal-Hargreaves, Nicholas F., et al.
Publicado: (2017)

Correction: Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130CAS/Src inhibition by eribulin
por: Dybdal-Hargreaves, Nicholas F., et al.
Publicado: (2019)

Telomere Maintenance and the cGAS-STING Pathway in Cancer
por: Ebata, Hiroshi, et al.
Publicado: (2022)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
por: Hong, Christy, et al.
Publicado: (2019)

Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential
por: Fermaintt, Charles S., et al.
Publicado: (2021)

Eribulin and Paclitaxel Differentially Alter Extracellular Vesicles and Their Cargo from Triple-Negative Breast Cancer Cells
por: Pederson, Petra J., et al.
Publicado: (2021)

cGAS-STING pathway in cancer biotherapy
por: Wang, Yang, et al.
Publicado: (2020)

Attenuation of cGAS/STING activity during mitosis
por: Uhlorn, Brittany L, et al.
Publicado: (2020)

The Complexity of the cGAS-STING Pathway in CNS Pathologies
por: Fryer, Amelia L., et al.
Publicado: (2021)

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
por: Kim, Jeonghan, et al.
Publicado: (2023)

Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS
por: Webb, L. G., et al.
Publicado: (2020)

cGAS-STING pathway in oncogenesis and cancer therapeutics
por: Hoong, Brandon Yi Da, et al.
Publicado: (2020)

The interactions between cGAS-STING pathway and pathogens
por: Cheng, Zhangliang, et al.
Publicado: (2020)

cGAS-STING, an important pathway in cancer immunotherapy
por: Jiang, Minlin, et al.
Publicado: (2020)

The role of cGAS-STING signalling in liver diseases
por: Chen, Ruihan, et al.
Publicado: (2021)

cGAS/STING: novel perspectives of the classic pathway
por: Gao, Menghui, et al.
Publicado: (2020)

Advances in cGAS-STING Signaling Pathway and Diseases
por: Yang, Yuting, et al.
Publicado: (2022)

Mitotic inactivation of the cGAS‒MITA/STING pathways
por: Zhong, Li, et al.
Publicado: (2021)

Intercellular transmission of cGAS-STING signaling in cancer
por: Wu, Qirou, et al.
Publicado: (2023)

Role of cGAS–Sting Signaling in Alzheimer’s Disease
por: Govindarajulu, Manoj, et al.
Publicado: (2023)

The Activation of cGAS-STING in Acute Kidney Injury
por: Sun, Chuanchuan, et al.
Publicado: (2023)

Targeting the loss of cGAS/STING signaling in cancer
por: Sasaki, Nobunari, et al.
Publicado: (2023)

Significance of the cGAS-STING Pathway in Health and Disease
por: Zhou, Jinglin, et al.
Publicado: (2023)

cGAS-STING triggers inflammaging-associated neurodegeneration
por: Izquierdo, José M.
Publicado: (2023)

Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway
por: Zhou, Lu, et al.
Publicado: (2021)

Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes
por: McLemore, Amy F., et al.
Publicado: (2022)

The cGAS-STING Defense Pathway and Its Counteraction by Viruses
por: Ma, Zhe, et al.
Publicado: (2016)

cGAS-independent STING activation in response to DNA damage
por: Unterholzner, Leonie, et al.
Publicado: (2019)

Conserved strategies for pathogen evasion of cGAS–STING immunity
por: Eaglesham, James B, et al.
Publicado: (2020)

The cGAS-STING Pathway in Hematopoiesis and Its Physiopathological Significance
por: Liao, Weinian, et al.
Publicado: (2020)

Activation of the cGAS–STING signaling pathway in adenomyosis patients
por: Lin, Yun, et al.
Publicado: (2021)

Activation of cGAS/STING pathway upon paramyxovirus infection
por: Iampietro, Mathieu, et al.
Publicado: (2021)

The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer
por: Mohseni, Ghazal, et al.
Publicado: (2021)

The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity
por: Liu, Nanxin, et al.
Publicado: (2022)

The cGAS-STING Pathway: Novel Perspectives in Liver Diseases
por: Xu, Dongwei, et al.
Publicado: (2021)

The cGAS-STING Pathway: A Promising Immunotherapy Target
por: Ou, Liang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_23st5vkags51bvm9ar23ogfket