Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein–coupled receptor and mainstay therapeutic target for the treatment of type 2 diabetes and obesity. Recent reports have highlighted how biased agonism at the GLP-1R affects sustained glucose-stimulated insulin secretion through avoi...

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Detalles Bibliográficos
Autores principales: Lucey, Maria, Ashik, Tanyel, Marzook, Amaara, Wang, Yifan, Goulding, Joëlle, Oishi, Atsuro, Broichhagen, Johannes, Hodson, David J., Minnion, James, Elani, Yuval, Jockers, Ralf, Briddon, Stephen J., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626645/
https://www.ncbi.nlm.nih.gov/pubmed/34315812
http://dx.doi.org/10.1124/molpharm.121.000270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626645/
https://www.ncbi.nlm.nih.gov/pubmed/34315812
http://dx.doi.org/10.1124/molpharm.121.000270

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