Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro

Tenofovir (TFV) is a key component of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP). TFV is a nucleotide analog reverse-transcriptase inhibitor prodrug that requires two separate phosphorylation reactions by intracellular kinases to form the active metabolite tenofovir-diphospha...

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Detalles Bibliográficos
Autores principales: Mosher, Eric P., Eberhard, Colten D., Bumpus, Namandjé N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626780/
https://www.ncbi.nlm.nih.gov/pubmed/34561299
http://dx.doi.org/10.1124/molpharm.121.000348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626780/
https://www.ncbi.nlm.nih.gov/pubmed/34561299
http://dx.doi.org/10.1124/molpharm.121.000348

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