Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction

BACKGROUND: Exercise can protect myocardial infarction (MI) and downregulate cardiac Homeodomain-Interacting Protein Kinase 2 (HIPK2). However, the role of HIPK2 in MI is unclear. METHODS: HIPK2(–/–) mice and miR-222(–/–) rats, HIPK2 inhibitor (PKI1H) and adeno-associated virus serotype 9 (AAV9) car...

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Detalles Bibliográficos
Autores principales: Zhou, Qiulian, Deng, Jiali, Yao, Jianhua, Song, Jiaxin, Meng, Danni, Zhu, Yujiao, Xu, Minjun, Liang, Yajun, Xu, Jiahong, Sluijter, Joost PG, Xiao, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626841/
https://www.ncbi.nlm.nih.gov/pubmed/34837851
http://dx.doi.org/10.1016/j.ebiom.2021.103713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626841/
https://www.ncbi.nlm.nih.gov/pubmed/34837851
http://dx.doi.org/10.1016/j.ebiom.2021.103713

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