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Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction
BACKGROUND: Exercise can protect myocardial infarction (MI) and downregulate cardiac Homeodomain-Interacting Protein Kinase 2 (HIPK2). However, the role of HIPK2 in MI is unclear. METHODS: HIPK2(–/–) mice and miR-222(–/–) rats, HIPK2 inhibitor (PKI1H) and adeno-associated virus serotype 9 (AAV9) car...
Autores principales: | Zhou, Qiulian, Deng, Jiali, Yao, Jianhua, Song, Jiaxin, Meng, Danni, Zhu, Yujiao, Xu, Minjun, Liang, Yajun, Xu, Jiahong, Sluijter, Joost PG, Xiao, Junjie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626841/ https://www.ncbi.nlm.nih.gov/pubmed/34837851 http://dx.doi.org/10.1016/j.ebiom.2021.103713 |
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