Cargando…

Metformin attenuates LPS-induced neuronal injury and cognitive impairments by blocking NF-κB pathway

BACKGROUND: Neuroinflammatory response is considered to be a high-risk factor for cognitive impairments in the brain. Lipopolysaccharides (LPS) is an endotoxin that induces acute inflammatory responses in injected bodies. However, the molecular mechanisms underlying LPS-associated cognitive impairme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Chenliang, Peng, Bo, Qin, Zhenghui, Zhu, Wei, Guo, Cuiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626880/ https://www.ncbi.nlm.nih.gov/pubmed/34836498 http://dx.doi.org/10.1186/s12868-021-00678-5

Ejemplares similares

Metformin attenuates sepsis-induced neuronal injury and cognitive impairment
por: Qin, Zhenghui, et al.
Publicado: (2021)

Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation
por: Zhang, Bo, et al.
Publicado: (2017)

NF-κB inhibition attenuates LPS-induced TLR4 activation in monocyte cells
por: Wan, Jian, et al.
Publicado: (2016)

Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway
por: Badshah, Haroon, et al.
Publicado: (2016)

Alprostadil attenuates LPS-induced cardiomyocyte injury by inhibiting the Wnt5a/JNK/NF-κB pathway
por: Yu, T., et al.
Publicado: (2019)

Xuanfei Baidu Formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway
por: Zhu, Yanru, et al.
Publicado: (2023)

(+)-JQ1 attenuated LPS-induced microglial inflammation via MAPK/NFκB signaling
por: Wang, Huanhuan, et al.
Publicado: (2018)

Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-κB Pathway
por: Kim, Eun Jeong, et al.
Publicado: (2015)

AMPK Inhibition Blocks ROS-NFκB Signaling and Attenuates Endotoxemia-Induced Liver Injury
por: Guo, Yuan, et al.
Publicado: (2014)

Andrographolide Protects against LPS-Induced Acute Lung Injury by Inactivation of NF-κB
por: Zhu, Tao, et al.
Publicado: (2013)

Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice
por: Go, Jun, et al.
Publicado: (2022)

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling
por: Muhammad, Tahir, et al.
Publicado: (2019)

Metformin Attenuates Ischemia-reperfusion Injury of Fatty Liver in Rats Through Inhibition of the TLR4/NF-κB Axis
por: Li, Xiaohua, et al.
Publicado: (2020)

Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF-κB/NLRP3 Pathway and Inhibiting Endothelial Cell Pyroptosis
por: Zhang, Yunqian, et al.
Publicado: (2022)

Nicorandil Attenuates LPS-Induced Acute Lung Injury by Pulmonary Endothelial Cell Protection via NF-κB and MAPK Pathways
por: He, Mengyu, et al.
Publicado: (2019)

Geraniin attenuates LPS-induced acute lung injury via inhibiting NF-κB and activating Nrf2 signaling pathways
por: Zhu, Guangfa, et al.
Publicado: (2017)

Lianqinjiedu decoction attenuates LPS-induced inflammation and acute lung injury in rats via TLR4/NF-κB pathway
por: Deng, Guiming, et al.
Publicado: (2017)

Cul4a attenuates LPS-induced acute kidney injury via blocking NF-kB signaling pathway in sepsis
por: Zhao, Jing, et al.
Publicado: (2022)

Inosine Pretreatment Attenuates LPS-Induced Lung Injury through Regulating the TLR4/MyD88/NF-κB Signaling Pathway In Vivo
por: Mao, Bingyong, et al.
Publicado: (2022)

Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium()
por: Xie, Hong, et al.
Publicado: (2012)

METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway
por: Wang, Jinghua, et al.
Publicado: (2019)

PARP-1 Inhibitor, DPQ, Attenuates LPS-Induced Acute Lung Injury through Inhibiting NF-κB-Mediated Inflammatory Response
por: Wang, Gang, et al.
Publicado: (2013)

Anti-Inflammatory Pyranochalcone Derivative Attenuates LPS-Induced Acute Kidney Injury via Inhibiting TLR4/NF-κB Pathway
por: Shi, Min, et al.
Publicado: (2017)

The Role of Autophagy in Kidney Inflammatory Injury via the NF-κB Route Induced by LPS
por: Wu, Yu, et al.
Publicado: (2015)

Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury
por: Xiao, Kun, et al.
Publicado: (2020)

Activation of the IL-17/TRAF6/NF-κB pathway is implicated in Aβ-induced neurotoxicity
por: Liu, Yulan, et al.
Publicado: (2023)

Safflower Seed Extract Attenuates the Development of Osteoarthritis by Blocking NF-κB Signaling
por: Han, Seong Jae, et al.
Publicado: (2021)

Carnosol Attenuates LPS-Induced Inflammation of Cardiomyoblasts by Inhibiting NF-κB: A Mechanistic in Vitro and in Silico Study
por: Baradaran Rahimi, Vafa, et al.
Publicado: (2022)

Correction: Activation of the IL-17/TRAF6/NF-κB pathway is implicated in Aβ-induced neurotoxicity
por: Liu, Yulan, et al.
Publicado: (2023)

Emodin Ameliorates LPS-Induced Acute Lung Injury, Involving the Inactivation of NF-κB in Mice
por: Xiao, Min, et al.
Publicado: (2014)

Transcriptional profiling of the LPS induced NF-κB response in macrophages
por: Sharif, Omar, et al.
Publicado: (2007)

Mechanism of Metformin on LPS-Induced Bacterial Myocarditis
por: Li, Minghua, et al.
Publicado: (2019)

Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway
por: Xiang, Nan-lin, et al.
Publicado: (2016)

Micheliolide attenuates neuroinflammation to improve cognitive impairment of Alzheimer's disease by inhibiting NF-κB and PI3K/Akt signaling pathways
por: Yang, Guizhen, et al.
Publicado: (2023)

HMBOX1 attenuates LPS-induced periodontal ligament stem cell injury by inhibiting CXCL10 expression through the NF-κB signaling pathway
por: Nie, Minyuan, et al.
Publicado: (2022)

Pterostilbene Attenuates Astrocytic Inflammation and Neuronal Oxidative Injury After Ischemia-Reperfusion by Inhibiting NF-κB Phosphorylation
por: Liu, Haixiao, et al.
Publicado: (2019)

AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages
por: Kirchner, Johannes, et al.
Publicado: (2018)

Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer’s disease via inhibiting NF-κB signaling pathway
por: He, Li, et al.
Publicado: (2023)

Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB
por: An, Ning, et al.
Publicado: (2021)

RKC-B1 Blocks Activation of NF-κB and NLRP3 Signaling Pathways to Suppress Neuroinflammation in LPS-Stimulated Mice
por: Liu, Man, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m9ot9569jtsnj466dhl36phhf5