Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

MYC is a prolific proto-oncogene driving the malignant behaviors of numerous common cancers, yet potent and selective cell-permeable inhibitors of MYC remain elusive. In order to ultimately realize the goal of therapeutic MYC inhibition in cancer, we have initiated discovery chemistry efforts aimed...

Descripción completa

Detalles Bibliográficos
Autores principales: Gill, Taylor, Wang, Haichuan, Bandaru, Raj, Lawlor, Matthew, Lu, Chenyue, Nieman, Linda T., Tao, Junyan, Zhang, Yixian, Anderson, Daniel G., Ting, David T., Chen, Xin, Bradner, James E., Ott, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627489/
https://www.ncbi.nlm.nih.gov/pubmed/34650218
http://dx.doi.org/10.1038/s41388-021-02053-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627489/
https://www.ncbi.nlm.nih.gov/pubmed/34650218
http://dx.doi.org/10.1038/s41388-021-02053-4

Ejemplares similares