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Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

MYC is a prolific proto-oncogene driving the malignant behaviors of numerous common cancers, yet potent and selective cell-permeable inhibitors of MYC remain elusive. In order to ultimately realize the goal of therapeutic MYC inhibition in cancer, we have initiated discovery chemistry efforts aimed...

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Detalles Bibliográficos
Autores principales:	Gill, Taylor, Wang, Haichuan, Bandaru, Raj, Lawlor, Matthew, Lu, Chenyue, Nieman, Linda T., Tao, Junyan, Zhang, Yixian, Anderson, Daniel G., Ting, David T., Chen, Xin, Bradner, James E., Ott, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627489/ https://www.ncbi.nlm.nih.gov/pubmed/34650218 http://dx.doi.org/10.1038/s41388-021-02053-4

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