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Interactions between nascent proteins and the ribosome surface inhibit co-translational folding
Most proteins begin to fold during biosynthesis on the ribosome. It has been suggested that interactions between the emerging polypeptide and the ribosome surface might allow the ribosome itself to modulate co-translational folding. Here we combine protein engineering and NMR spectroscopy to charact...
Autores principales: | Cassaignau, Anaïs M. E., Włodarski, Tomasz, Chan, Sammy H. S., Woodburn, Lauren F., Bukvin, Ivana V., Streit, Julian O., Cabrita, Lisa D., Waudby, Christopher A., Christodoulou, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627912/ https://www.ncbi.nlm.nih.gov/pubmed/34650236 http://dx.doi.org/10.1038/s41557-021-00796-x |
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