Photoreactive-proton-generating hyaluronidase/albumin nanoparticles-loaded PEG-hydrogel enhances antitumor efficacy and disruption of the hyaluronic acid extracellular matrix in AsPC-1 tumors

Depletion of tumor extracellular matrix (ECM) is viewed as a promising approach to enhance the antitumor efficacy of chemotherapeutic-loaded nanoparticles. Hyaluronidase (HAase) destroys hyaluronic acid-based tumor ECM, but it is active solely at acidic pHs of around 5.0 and is much less active at p...

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Detalles Bibliográficos
Autores principales: Lee, Woo Tak, Lee, Junyeong, Kim, Hanju, Nguyen, Nguyen Thi, Lee, Eun Seong, Oh, Kyung Taek, Choi, Han-Gon, Youn, Yu Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627971/
https://www.ncbi.nlm.nih.gov/pubmed/34877519
http://dx.doi.org/10.1016/j.mtbio.2021.100164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627971/
https://www.ncbi.nlm.nih.gov/pubmed/34877519
http://dx.doi.org/10.1016/j.mtbio.2021.100164

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