Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy

BACKGROUND: The critical role of phosphoinositide 3-kinase (PI3K) activation in tumor cell biology has prompted massive efforts to develop PI3K inhibitors (PI3Kis) for cancer therapy. However, recent results from clinical trials have shown only a modest therapeutic efficacy of single-agent PI3Kis in...

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Detalles Bibliográficos
Autores principales: Peng, Xin, Zhang, Shaolu, Jiao, Wenhui, Zhong, Zhenxing, Yang, Yuqi, Claret, Francois X., Elkabets, Moshe, Wang, Feng, Wang, Ran, Zhong, Yuxu, Chen, Zhe-Sheng, Kong, Dexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628289/
https://www.ncbi.nlm.nih.gov/pubmed/34844627
http://dx.doi.org/10.1186/s13046-021-02176-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628289/
https://www.ncbi.nlm.nih.gov/pubmed/34844627
http://dx.doi.org/10.1186/s13046-021-02176-2

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