Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor

OBJECTIVE: We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later. The present study was undertaken to investigate whether PF06426779 could reverse the lup...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrova, Tsvetana, Nanda, Sambit K, Scudamore, Cheryl, Wright, Stephen W, Rao, Vikram R, Cohen, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628323/
https://www.ncbi.nlm.nih.gov/pubmed/34836923
http://dx.doi.org/10.1136/lupus-2021-000573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628323/
https://www.ncbi.nlm.nih.gov/pubmed/34836923
http://dx.doi.org/10.1136/lupus-2021-000573

Ejemplares similares