mGlu(1) potentiation enhances prelimbic somatostatin interneuron activity to rescue schizophrenia-like physiological and cognitive deficits

Evidence for prefrontal cortical (PFC) GABAergic dysfunction is one of the most consistent findings in schizophrenia and may contribute to cognitive deficits. Recent studies suggest that the mGlu(1) subtype of metabotropic glutamate receptor regulates cortical inhibition; however, understanding the...

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Detalles Bibliográficos
Autores principales: Maksymetz, James, Byun, Nellie E., Luessen, Deborah J., Li, Brianna, Barry, Robert L., Gore, John C., Niswender, Colleen M., Lindsley, Craig W., Joffe, Max E., Conn, P. Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628371/
https://www.ncbi.nlm.nih.gov/pubmed/34731619
http://dx.doi.org/10.1016/j.celrep.2021.109950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628371/
https://www.ncbi.nlm.nih.gov/pubmed/34731619
http://dx.doi.org/10.1016/j.celrep.2021.109950

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