Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss

KCNQ4 encodes the homotetrameric voltage-dependent potassium ion channel Kv7.4, and is the causative gene for autosomal dominant nonsyndromic sensorineural hearing loss, DFNA2. Dominant-negative inhibition accounts for the observed dominant inheritance of many DFNA2-associated KCNQ4 variants. In add...

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Detalles Bibliográficos
Autores principales: Kojima, Takashi, Wasano, Koichiro, Takahashi, Satoe, Homma, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628632/
https://www.ncbi.nlm.nih.gov/pubmed/34622280
http://dx.doi.org/10.1242/dmm.049015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628632/
https://www.ncbi.nlm.nih.gov/pubmed/34622280
http://dx.doi.org/10.1242/dmm.049015

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