Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning

Stabilizing antigenic proteins as vaccine immunogens or diagnostic reagents is a stringent case of protein engineering and design as the exterior surface must maintain recognition by receptor(s) and antigen—specific antibodies at multiple distinct epitopes. This is a challenge, as stability-enhancin...

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Detalles Bibliográficos
Autores principales: Leonard, Alison C., Weinstein, Jonathan J., Steiner, Paul J., Erbse, Annette H., Fleishman, Sarel J., Whitehead, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629191/
https://www.ncbi.nlm.nih.gov/pubmed/34845448
http://dx.doi.org/10.1101/2021.11.22.469552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629191/
https://www.ncbi.nlm.nih.gov/pubmed/34845448
http://dx.doi.org/10.1101/2021.11.22.469552

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