LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans

SARS-CoV-2 infection is mediated by the entry receptor ACE2. Although attachment factors and co-receptors facilitating entry are extensively studied, cellular entry factors inhibiting viral entry are largely unknown. Using a surfaceome CRISPR activation screen, we identified human LRRC15 as an inhib...

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Detalles Bibliográficos
Autores principales: Song, Jaewon, Chow, Ryan D., Pena-Hernandez, Mario, Zhang, Li, Loeb, Skylar A., So, Eui-Young, Liang, Olin D., Wilen, Craig B., Lee, Sanghyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629192/
https://www.ncbi.nlm.nih.gov/pubmed/34845449
http://dx.doi.org/10.1101/2021.11.23.469714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629192/
https://www.ncbi.nlm.nih.gov/pubmed/34845449
http://dx.doi.org/10.1101/2021.11.23.469714

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