Ca(2+) administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis

The capacity of a cell to maintain proteostasis progressively declines during aging. Virtually all age-associated neurodegenerative disorders associated with aggregation of neurotoxic proteins are linked to defects in the cellular proteostasis network, including insufficient lysosomal hydrolysis. He...

Descripción completa

Detalles Bibliográficos
Autores principales: Habernig, Lukas, Broeskamp, Filomena, Aufschnaiter, Andreas, Diessl, Jutta, Peselj, Carlotta, Urbauer, Elisabeth, Eisenberg, Tobias, de Ory, Ana, Büttner, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629384/
https://www.ncbi.nlm.nih.gov/pubmed/34780474
http://dx.doi.org/10.1371/journal.pgen.1009911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629384/
https://www.ncbi.nlm.nih.gov/pubmed/34780474
http://dx.doi.org/10.1371/journal.pgen.1009911

Ejemplares similares