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Ca(2+) administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis
The capacity of a cell to maintain proteostasis progressively declines during aging. Virtually all age-associated neurodegenerative disorders associated with aggregation of neurotoxic proteins are linked to defects in the cellular proteostasis network, including insufficient lysosomal hydrolysis. He...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629384/ https://www.ncbi.nlm.nih.gov/pubmed/34780474 http://dx.doi.org/10.1371/journal.pgen.1009911 |