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Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase

Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of cancer and linked to cancer genome evolution. Errors can manifest as “lagging chromosomes” in anaphase, although their mechanistic origins and likelihood of correction are incompletely understood. Here, we combine...

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Detalles Bibliográficos
Autores principales: Sen, Onur, Harrison, Jonathan U., Burroughs, Nigel J., McAinsh, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629432/
https://www.ncbi.nlm.nih.gov/pubmed/34758290
http://dx.doi.org/10.1016/j.devcel.2021.10.007