Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency

PURPOSE: The etiology of premature ovarian insufficiency (POI) is heterogeneous, and genetic factors account for 20–25% of the patients. The primordial follicle pool is determined by the meiosis process, which is initiated by programmed DNA double strand breaks (DSB) and homologous recombination. Th...

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Detalles Bibliográficos
Autores principales: Wang, Yiyang, Guo, Ting, Ke, Hanni, Zhang, Qian, Li, Shan, Luo, Wei, Qin, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629753/
https://www.ncbi.nlm.nih.gov/pubmed/34257419
http://dx.doi.org/10.1038/s41436-021-01266-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629753/
https://www.ncbi.nlm.nih.gov/pubmed/34257419
http://dx.doi.org/10.1038/s41436-021-01266-y

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