Cargando…
Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant
The lipophilic polycyclic aromatic hydrocarbon (PAH) phenanthrene is relatively abundant in polluted air and water and can access and accumulate in human tissue. Phenanthrene has been reported to interact with cardiac ion channels in several fish species. This study was undertaken to investigate the...
Autores principales: | Al-Moubarak, Ehab, Shiels, Holly A., Zhang, Yihong, Du, Chunyun, Hanington, Oliver, Harmer, Stephen C., Dempsey, Christopher E., Hancox, Jules C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629796/ https://www.ncbi.nlm.nih.gov/pubmed/34727194 http://dx.doi.org/10.1007/s00018-021-03967-8 |
Ejemplares similares
-
Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure
por: Zhang, Yihong, et al.
Publicado: (2020) -
Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration
por: Melgari, Dario, et al.
Publicado: (2014) -
Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants
por: Du, Chunyun, et al.
Publicado: (2014) -
Serine mutation of a conserved threonine in the hERG K(+) channel S6-pore region leads to loss-of-function through trafficking impairment
por: Al-Moubarak, Ehab, et al.
Publicado: (2020) -
An Update on the Structure of hERG
por: Butler, Andrew, et al.
Publicado: (2020)