Lipin-1-derived diacylglycerol activates intracellular TRPC3 which is critical for inflammatory signaling

Exposure to Gram-negative bacterial LPS exacerbates host immune responses and may lead to sepsis, a life-threatening condition. Despite its high mortality and morbidity, no drugs specifically directed to treating sepsis are currently available. Using human cell genetic depletion, pharmacological inh...

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Detalles Bibliográficos
Autores principales: Casas, Javier, Meana, Clara, López-López, José Ramón, Balsinde, Jesús, Balboa, María A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629864/
https://www.ncbi.nlm.nih.gov/pubmed/34757442
http://dx.doi.org/10.1007/s00018-021-03999-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629864/
https://www.ncbi.nlm.nih.gov/pubmed/34757442
http://dx.doi.org/10.1007/s00018-021-03999-0

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