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Lipin-1-derived diacylglycerol activates intracellular TRPC3 which is critical for inflammatory signaling
Exposure to Gram-negative bacterial LPS exacerbates host immune responses and may lead to sepsis, a life-threatening condition. Despite its high mortality and morbidity, no drugs specifically directed to treating sepsis are currently available. Using human cell genetic depletion, pharmacological inh...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629864/ https://www.ncbi.nlm.nih.gov/pubmed/34757442 http://dx.doi.org/10.1007/s00018-021-03999-0 |