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Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes
Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA...
Huvudupphovsmän: | , , , |
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Materialtyp: | Online Artikel Text |
Språk: | English |
Publicerad: |
Springer International Publishing
2021
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Ämnen: | |
Länkar: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629891/ https://www.ncbi.nlm.nih.gov/pubmed/34731255 http://dx.doi.org/10.1007/s00018-021-03984-7 |