Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes

Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Apelt, Katja, Lans, Hannes, Schärer, Orlando D., Luijsterburg, Martijn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629891/
https://www.ncbi.nlm.nih.gov/pubmed/34731255
http://dx.doi.org/10.1007/s00018-021-03984-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629891/
https://www.ncbi.nlm.nih.gov/pubmed/34731255
http://dx.doi.org/10.1007/s00018-021-03984-7

Ejemplares similares