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OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1

High-affinity uptake of natural nucleosides as well as nucleoside derivatives used in anticancer therapies is mediated by human concentrative nucleoside transporters (hCNTs). hCNT1, the hCNT family member that specifically transports pyrimidines, is also a transceptor involved in tumor progression....

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Detalles Bibliográficos
Autores principales: Boces-Pascual, Clara, Mata-Ventosa, Aida, Martín-Satué, Mireia, Boix, Loreto, Gironella, Meritxell, Pastor-Anglada, Marçal, Pérez-Torras, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629896/
https://www.ncbi.nlm.nih.gov/pubmed/34647142
http://dx.doi.org/10.1007/s00018-021-03959-8