Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

The membrane protein Dispatched (Disp), which belongs to the RND family of small molecule transporters, is essential for Hedgehog (Hh) signaling, by catalyzing the extracellular release of palmitate- and cholesterol-modified Hh ligands from producing cells. Disp function requires Furin-mediated prot...

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Detalles Bibliográficos
Autores principales: Li, Wanqiu, Wang, Linlin, Wierbowski, Bradley M., Lu, Mo, Dong, Feitong, Liu, Wenchen, Li, Sisi, Wang, Peiyi, Salic, Adrian, Gong, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630017/
https://www.ncbi.nlm.nih.gov/pubmed/34845226
http://dx.doi.org/10.1038/s41467-021-27257-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630017/
https://www.ncbi.nlm.nih.gov/pubmed/34845226
http://dx.doi.org/10.1038/s41467-021-27257-w

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