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Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
Within the bone marrow microenvironment, endothelial cells (EC) exert important functions. Arterial EC support hematopoiesis while H-type capillaries induce bone formation. Here, we show that BM sinusoidal EC (BM-SEC) actively control erythropoiesis. Mice with stabilized β-catenin in BM-SEC (Ctnnb1(...
Autores principales: | Heil, Joschka, Olsavszky, Victor, Busch, Katrin, Klapproth, Kay, de la Torre, Carolina, Sticht, Carsten, Sandorski, Kajetan, Hoffmann, Johannes, Schönhaber, Hiltrud, Zierow, Johanna, Winkler, Manuel, Schmid, Christian David, Staniczek, Theresa, Daniels, Deborah E., Frayne, Jan, Metzgeroth, Georgia, Nowak, Daniel, Schneider, Sven, Neumaier, Michael, Weyer, Vanessa, Groden, Christoph, Gröne, Hermann-Josef, Richter, Karsten, Mogler, Carolin, Taketo, Makoto Mark, Schledzewski, Kai, Géraud, Cyrill, Goerdt, Sergij, Koch, Philipp-Sebastian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630019/ https://www.ncbi.nlm.nih.gov/pubmed/34845225 http://dx.doi.org/10.1038/s41467-021-27161-3 |
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