Cargando…

A general strategy for C(sp(3))–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor

Photoredox catalysis has provided many approaches to C(sp(3))–H functionalization that enable selective oxidation and C(sp(3))–C bond formation via the intermediacy of a carbon-centered radical. While highly enabling, functionalization of the carbon-centered radical is largely mediated by electrophi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leibler, Isabelle Nathalie-Marie, Tekle-Smith, Makeda A., Doyle, Abigail G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630022/ https://www.ncbi.nlm.nih.gov/pubmed/34845207 http://dx.doi.org/10.1038/s41467-021-27165-z

Ejemplares similares

Abstracting scientific and technical literature: an introductory guide and text for scientists, abstractors and management
por: Maizell, Robert E, et al.
Publicado: (1971)

Radical Redox Annulations: A General Light-Driven Method for the Synthesis of Saturated Heterocycles
por: Murray, Philip R. D., et al.
Publicado: (2022)

Nucleophilic Substitution (S(N)2): Dependence on Nucleophile, Leaving Group, Central Atom, Substituents, and Solvent
por: Hamlin, Trevor A., et al.
Publicado: (2018)

Harnessing Ionic Interactions and Hydrogen Bonding for Nucleophilic Fluorination
por: Oh, Young-Ho, et al.
Publicado: (2020)

Vitamin B(12) and hydrogen atom transfer cooperative catalysis as a hydride nucleophile mimic in epoxide ring opening
por: Funk, Brian E., et al.
Publicado: (2023)

Difunctionalization of Alkenes and Alkynes via Intermolecular Radical and Nucleophilic Additions
por: Yao, Hongjun, et al.
Publicado: (2020)

Reactions of Methyl Radicals with Aniline Acting as Hydrogen Donors and as Methyl Radical Acceptors
por: Pham, Tien V., et al.
Publicado: (2023)

General Strategy toward Hydrophilic Single Atom Catalysts for Efficient Selective Hydrogenation
por: Ling, Yuxuan, et al.
Publicado: (2022)

Site-specific hydrogen-atom elimination in photoexcited ethyl radical
por: Chicharro, David V., et al.
Publicado: (2019)

Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes
por: Potrząsaj, Aleksandra, et al.
Publicado: (2022)

Chemical Kinetics of Hydrogen Atom Abstraction from Propargyl Sites by Hydrogen and Hydroxy Radicals
por: Wang, Quan-De, et al.
Publicado: (2019)

An umpolung strategy to react catalytic enols with nucleophiles
por: Sanz-Marco, Amparo, et al.
Publicado: (2019)

Direct Amination of Nitroquinoline Derivatives via Nucleophilic Displacement of Aromatic Hydrogen
por: Wantulok, Jakub, et al.
Publicado: (2021)

General Allylic C–H Alkylation with Tertiary Nucleophiles
por: Howell, Jennifer M., et al.
Publicado: (2014)

Additions of Aldehyde-Derived Radicals and Nucleophilic N-Alkylindoles to Styrenes by Photoredox Catalysis
por: Lux, Marcel, et al.
Publicado: (2020)

Radical cascade synthesis of azoles via tandem hydrogen atom transfer
por: Chen, Andrew D., et al.
Publicado: (2020)

Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(sp(3))–H allylation of 4-alkylpyridines
por: Wasfy, Nour, et al.
Publicado: (2020)

Stereoselective hydrogen atom transfer to acyclic radicals: a switch enabling diastereodivergent borylative radical cascades
por: Ye, Tian, et al.
Publicado: (2022)

Efficient Difluoromethylation of sp(3) Carbon Nucleophiles by Bromodifluoromethylation Reagents with Organic Bases
por: Liu, Guokai, et al.
Publicado: (2012)

Factors Governing Reactivity and Selectivity in Hydrogen Atom Transfer from C(sp(3))–H Bonds of Nitrogen-Containing Heterocycles to the Cumyloxyl Radical
por: Galeotti, Marco, et al.
Publicado: (2022)

Nucleophilic Isocyanation
por: Yurino, Taiga, et al.
Publicado: (2020)

Photoinduced 1,2-dicarbofunctionalization of alkenes with organotrifluoroborate nucleophiles via radical/polar crossover
por: Cabrera-Afonso, María Jesús, et al.
Publicado: (2021)

Catalytic Synthesis of Indolines by Hydrogen Atom Transfer to Cobalt(III)–Carbene Radicals
por: Karns, Alexander S., et al.
Publicado: (2017)

Catalytic hydrogen atom transfer to alkenes: a roadmap for metal hydrides and radicals
por: Shevick, Sophia L., et al.
Publicado: (2020)

DFT Investigation of Hydrogen Atom Abstraction from NHC-Boranes by Methyl, Ethyl and Cyanomethyl Radicals—Composition and Correlation Analysis of Kinetic Barriers
por: Qu, Hong-jie, et al.
Publicado: (2020)

Palladium-catalyzed substitution of (coumarinyl)methyl acetates with C-, N-, and S-nucleophiles
por: Chattopadhyay, Kalicharan, et al.
Publicado: (2012)

Regiodivergent Nucleophilic Fluorination under Hydrogen Bonding Catalysis: A Computational and Experimental Study
por: Horwitz, Matthew A., et al.
Publicado: (2023)

Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines
por: Galli, Ubaldina, et al.
Publicado: (2019)

Nucleophilic reactivity of the gold atom in a diarylborylgold(i) complex toward polar multiple bonds
por: Suzuki, Akane, et al.
Publicado: (2020)

EPR spin trapping of nucleophilic and radical reactions at colloidal metal chalcogenide quantum dot surfaces
por: Aschendorf, Caroline J., et al.
Publicado: (2023)

C–H functionalization reactions enabled by hydrogen atom transfer to carbon-centered radicals
por: Sarkar, Sumon, et al.
Publicado: (2020)

Radical ligand transfer: a general strategy for radical functionalization
por: Nemoto, David T, et al.
Publicado: (2023)

New Insight into the Chloroacetanilide Herbicide Degradation Mechanism through a Nucleophilic Attack of Hydrogen Sulfide
por: Mora, José R., et al.
Publicado: (2018)

Biomimetic hydrogen-bonding cascade for chemical activation: telling a nucleophile from a base
por: Park, Hyunchang, et al.
Publicado: (2020)

Ionic liquid cations as methylation agent for extremely weak chalcogenido metalate nucleophiles
por: Peters, Bertram, et al.
Publicado: (2019)

C(sp(3))-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (S(N)Ar)
por: Wales, Steven M., et al.
Publicado: (2022)

Cobalt-Catalyzed Methoxycarbonylation of Substituted Dichlorobenzenes as an Example of a Facile Radical Anion Nucleophilic Substitution in Chloroarenes
por: Khaibulova, Tatyana S., et al.
Publicado: (2014)

Photochemical generation of acyl and carbamoyl radicals using a nucleophilic organic catalyst: applications and mechanism thereof
por: de Pedro Beato, Eduardo, et al.
Publicado: (2020)

Kinetics of Hydrogen Atom Abstraction from Substrate by an Active Site Thiyl Radical in Ribonucleotide Reductase
por: Olshansky, Lisa, et al.
Publicado: (2014)

Quinone methide dimers lacking labile hydrogen atoms are surprisingly excellent radical-trapping antioxidants
por: Raycroft, Mark A. R., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8a1tovk3hpi9g3r5ocpmsb9p3q