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Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity
Obesity is a worldwide epidemic associated with increased risk and progression of colon cancer. Here, we aimed to determine the role of adipose triglyceride lipase (ATGL), responsible for intracellular lipid droplet (LD) utilization, in obesity-driven colonic tumorigenesis. In local colon cancer pat...
Autores principales: | Iftikhar, Rida, Penrose, Harrison M., King, Angelle N., Samudre, Joshua S., Collins, Morgan E., Hartono, Alifiani B., Lee, Sean B., Lau, Frank, Baddoo, Melody, Flemington, Erik F., Crawford, Susan E., Savkovic, Suzana D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630180/ https://www.ncbi.nlm.nih.gov/pubmed/34845203 http://dx.doi.org/10.1038/s41389-021-00373-4 |
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