Highly stereocontrolled total synthesis of racemic codonopsinol B through isoxazolidine-4,5-diol vinylation

A new highly diastereoselective synthesis of the polyhydroxylated pyrrolidine alkaloid (±)-codonopsinol B and its N-nor-methyl analogue, starting from achiral materials, is presented. The strategy relies on the trans-stereoselective epoxidation of 2,3-dihydroisoxazole with in situ-generated DMDO, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Ďurina, Lukáš, Ďurinová, Anna, Trejtnar, František, Janotka, Ľuboš, Messingerová, Lucia, Doháňošová, Jana, Moncol, Ján, Fischer, Róbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630432/
https://www.ncbi.nlm.nih.gov/pubmed/34900008
http://dx.doi.org/10.3762/bjoc.17.188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630432/
https://www.ncbi.nlm.nih.gov/pubmed/34900008
http://dx.doi.org/10.3762/bjoc.17.188

Ejemplares similares