Citrullinated Epitopes Identified on Tumour MHC Class II by Peptide Elution Stimulate Both Regulatory and Th1 Responses and Require Careful Selection for Optimal Anti-Tumour Responses

BACKGROUND: Somatic mutations or post-translational modifications of proteins result in changes that enable immune recognition. One such post-translational modification is citrullination, the conversion of arginine residues to citrulline. Citrullinated peptides are presented on MHC class II (MHCII)...

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Detalles Bibliográficos
Autores principales: Symonds, Peter, Marcu, Ana, Cook, Katherine W., Metheringham, Rachael L., Durrant, Lindy G., Brentville, Victoria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630742/
https://www.ncbi.nlm.nih.gov/pubmed/34858415
http://dx.doi.org/10.3389/fimmu.2021.764462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630742/
https://www.ncbi.nlm.nih.gov/pubmed/34858415
http://dx.doi.org/10.3389/fimmu.2021.764462

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