Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis

Accumulation of cytotoxic bile acids (BAs) during cholestasis can result in liver failure. Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by peroxisome proliferator–activated receptor alpha (PPARα). This study investigates the efficacy of adjunct fenof...

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Detalles Bibliográficos
Autores principales: Gallucci, Gina M., Trottier, Jocelyn, Hemme, Christopher, Assis, David N., Boyer, James L., Barbier, Olivier, Ghonem, Nisanne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631103/
https://www.ncbi.nlm.nih.gov/pubmed/34558841
http://dx.doi.org/10.1002/hep4.1787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631103/
https://www.ncbi.nlm.nih.gov/pubmed/34558841
http://dx.doi.org/10.1002/hep4.1787

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