WNK3 Maintains the GABAergic Inhibitory Tone, Synaptic Excitation and Neuronal Excitability via Regulation of KCC2 Cotransporter in Mature Neurons

The activation of chloride (Cl(−))permeable gamma (γ)-aminobutyric acid type A(GABA(A)) receptors induces synaptic inhibition in mature and excitation in immature neurons. This developmental “switch” in GABA function controlled by its polarity depends on the postnatal decrease in intraneuronal Cl(−)...

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Detalles Bibliográficos
Autores principales: Lim, Wee Meng, Chin, Eunice W. M., Tang, Bor Luen, Chen, Tingting, Goh, Eyleen L. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631424/
https://www.ncbi.nlm.nih.gov/pubmed/34858138
http://dx.doi.org/10.3389/fnmol.2021.762142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631424/
https://www.ncbi.nlm.nih.gov/pubmed/34858138
http://dx.doi.org/10.3389/fnmol.2021.762142

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