Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence

PfSPZ Vaccine against malaria is composed of Plasmodium falciparum (Pf) sporozoites (SPZ) manufactured using aseptically reared Anopheles stephensi mosquitoes. Immune response genes of Anopheles mosquitoes such as Leucin-Rich protein (LRIM1), inhibit Plasmodium SPZ development (sporogony) in mosquit...

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Detalles Bibliográficos
Autores principales: Inbar, Ehud, Eappen, Abraham G., Alford, Robert T., Reid, William, Harrell, Robert A., Hosseini, Maryam, Chakravarty, Sumana, Li, Tao, Sim, B. Kim Lee, Billingsley, Peter F., Hoffman, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631644/
https://www.ncbi.nlm.nih.gov/pubmed/34784388
http://dx.doi.org/10.1371/journal.ppat.1009770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631644/
https://www.ncbi.nlm.nih.gov/pubmed/34784388
http://dx.doi.org/10.1371/journal.ppat.1009770

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