Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site

Although myriad protein–protein interactions in nature use polyvalent binding, in which multiple ligands on one entity bind to multiple receptors on another, to date an affinity advantage of polyvalent binding has been demonstrated experimentally only in cases where the target receptor molecules are...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacham-Hartman, Shiran, Shmidov, Yulia, Radisky, Evette S., Bitton, Ronit, Lukatsky, David B., Papo, Niv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631645/
https://www.ncbi.nlm.nih.gov/pubmed/34847142
http://dx.doi.org/10.1371/journal.pone.0249616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631645/
https://www.ncbi.nlm.nih.gov/pubmed/34847142
http://dx.doi.org/10.1371/journal.pone.0249616

Ejemplares similares