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Computational Study of the Addition of Methanethiol to 40+ Michael Acceptors as a Model for the Bioconjugation of Cysteines
[Image: see text] A long series of Michael acceptors are studied computationally as potential alternatives to the maleimides that are used in most antibody–drug conjugates to link Cys of mAbs with cytotoxic drugs. The products of the reaction of methanethiol (CH(3)SH/MeSH, as a simple model of Cys)...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631706/ https://www.ncbi.nlm.nih.gov/pubmed/33914532 http://dx.doi.org/10.1021/acs.joc.1c00349 |