Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

A large number of inhibitory receptors recruit SHP1 and/or SHP2, tandem-SH2-containing phosphatases through phosphotyrosine-based motifs immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM). Despite the similarity, these receptors exhibit differ...

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Detalles Bibliográficos
Autores principales: Xu, Xiaozheng, Masubuchi, Takeya, Cai, Qixu, Zhao, Yunlong, Hui, Enfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631942/
https://www.ncbi.nlm.nih.gov/pubmed/34734802
http://dx.doi.org/10.7554/eLife.74276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631942/
https://www.ncbi.nlm.nih.gov/pubmed/34734802
http://dx.doi.org/10.7554/eLife.74276

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