HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease

Intestinal epithelial cells exist in physiological hypoxia, leading to hypoxia-inducible factor (HIF) activation and supporting barrier function and cell metabolism of the intestinal epithelium. In contrast, pathological hypoxia is a common feature of some chronic disorders, including inflammatory b...

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Detalles Bibliográficos
Autores principales: Knyazev, Evgeny, Maltseva, Diana, Raygorodskaya, Maria, Shkurnikov, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632048/
https://www.ncbi.nlm.nih.gov/pubmed/34858489
http://dx.doi.org/10.3389/fgene.2021.791640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632048/
https://www.ncbi.nlm.nih.gov/pubmed/34858489
http://dx.doi.org/10.3389/fgene.2021.791640

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