Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish

Macroautophagy/autophagy is known to be important for intracellular quality control in the lens. GJA8 is a major gap junction protein in vertebrate lenses. Mutations in GJA8 cause cataracts in humans. The well-known cataractogenesis mechanism is that mutated GJA8 leads to abnormal assembly of gap ju...

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Detalles Bibliográficos
Autores principales: Ping, Xiyuan, Liang, Jiancheng, Shi, Kexin, Bao, Jing, Wu, Jing, Yu, Xiaoning, Tang, Xiajing, Zou, Jian, Shentu, Xingchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632074/
https://www.ncbi.nlm.nih.gov/pubmed/33472493
http://dx.doi.org/10.1080/15548627.2021.1872188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632074/
https://www.ncbi.nlm.nih.gov/pubmed/33472493
http://dx.doi.org/10.1080/15548627.2021.1872188

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